Pronouns!
—because the set I'd settled on were:
zie / zim / zir / zirs / zirself
What can I say? Every set had its flaws, and no matter what I chose, folks would find reasons to complain, so I went with what seemed to have the fewest drawbacks. This set avoided self-collision (each form is distinct), maintained compatibility with common English phonemes, held audible distinctness from existing words, all of that.
Pronouns!
A couple months into my pronound-redefining campaign, "Invader Zim" hit the airwaves and I gave up, settling for "she" because at least nobody could justify screwing that up.
I'm actually just fine with "she" and "they" these days, and I'm really glad at least some segment of our society has finally made it to that point!