When 2e came out, I was in a hybrid game for a while which used some of Unearthed Arcana's rules since we weren't that well off and getting new rules books was a slow process - I played a cavalier.
By a different definition, though I've never been in the definition "homebrew" where people used D&D rules to create a completely new battery of wildly different races or class options (f'rex, trying to make Middle Earth, the Wild West with animal people, etc).